GW 441756

CAS No. 504433-23-2

GW 441756 ( GW-441756; GW 441756; GW441756 )

Catalog No. M17527 CAS No. 504433-23-2

GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 46 In Stock
10MG 72 In Stock
25MG 140 In Stock
50MG 213 In Stock
100MG 323 In Stock
500MG 764 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    GW 441756
  • Note
    Research use only, not for human use.
  • Brief Description
    GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.
  • Description
    GW-441756 is a potent inhibitor of TrkA (IC50 = 2 nM). Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma.
  • Synonyms
    GW-441756; GW 441756; GW441756
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    CDK2; C-Raf-1; TrkA
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    504433-23-2
  • Formula Weight
    275.3
  • Molecular Formula
    C17H13N3O
  • Purity
    98%
  • Solubility
    DMSO : 17.5 mg/mL. 63.57 mM; H2O : < 0.1 mg/mL
  • SMILES
    Cn1cc(c2ccccc12)C=C1c2c(cccn2)NC1=O
  • Chemical Name
    1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wood ER, et al. Bioorg Med Chem Lett, 2004, 14(4), 953-957.
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